rue21 is the largest fast-fashion retailer in the nation with over 1,100 stores. At rue21, we make the latest trends affordable and available to anyone, anywhere. Shop fun, fresh new trends and must-have styles at rue21 Chillicothe that don’t exist anywhere else! This includes girls and guys apparel, shoes, accessories, tech gadgets, beauty, and home decor. Stop by rue21 1075 N Bridge St and see what you've been missing!