rue21 is the largest fast-fashion retailer in the nation with over 1,100 stores. At rue21, we make the latest trends affordable and available to anyone, anywhere. Shop fun, fresh new trends and must-have styles at rue21 Lancaster that don’t exist anywhere else! This includes girls and guys apparel, shoes, accessories, tech gadgets, beauty, and home decor. Stop by rue21 1635 River Valley Circle S and see what you've been missing!